Drug profile of pharmacology ( Naloxone ) Essay

Drug profile of pharmacology ( Naloxone ) - Essay Example They also reverse the effect of the exogenous and endogenous opioid receptors by creating perceptible of opioid withdrawal in the opioid dependent patients. The common Opioid antagonists are naloxone and nalmefene and naltrexone are competitive antagonists for the opioid receptors. Naloxone is used primarily for the patients suffering from respiratory depression. 2. Naloxone – An introduction: Chemical name: â€Å"(-)-17-Allyl-4, 5a-epoxy-3, 14-dihydroxymorphinan-6-one.† (Sinatra, Jahr and Watkins-Pitchford, 2010). Generic Name: Naloxone Trade names: â€Å"Naloxone hydrochloride Injection (DBL or CSL brands), Naloxone Min-I-Jet Suboxone (in combination with Buprenorphine), Targin (in combination with oxycodone).† (Sinatra, Jahr and Watkins-Pitchford, 2010). Other Names: â€Å"L-Naloxone , N- Allylnoroxymorphone, Nalossone, Naloxona, Naloxone HCl, Naloxonum.† (Sinatra, Jahr and Watkins-Pitchford, 2010). Similar Ligands of Naloxone: Nalmefene, naltrexone, (+ ) – Naloxone, Naloxonazine, nalbuphine, naltriben and naltrindole, naloxone benzoylhydrazone, TRK820, beta – FNA, etorphine, diprenorphine, buprenorphine, nor-binalto and BNTX .(Sinatra, Jahr and Watkins-Pitchford, 2010). ... It is mainly used for managing opiate dependence syndrome and respiratory depressions caused by overdose of Opioids. The paramedic indications are: 1. Antinarcotic agents. 2. Narcotic antagonists. 3. Depressants. 4. Opiate Antagonists. 5. Reverse sedations caused by Opioids. 6. Respiratory depressants in neonatal care. 3. Mechanism of Action: Naloxone reverses the effect of the opioid overdose. Naloxone competitively binds to the opioid receptors and replaces the opioid molecules. By doing so, it reverses the effect of the agonists such as heroin. Naloxone is competitive antagonists at the mu, kappa and delta receptors. They have 10 fold greater affinity for the mu receptors. (Harvey and Champe 2008). Naloxone does not have any effect on the normal individuals but they precipitate the withdrawal symptoms at the abuse users. Animal studies have suggested that Naloxone inhibits GABA release and stimulates the cholinergic activity. Similarly they do not reverse the effects of ethanol. N aloxone first increases the local blood flow. (Harvey and Champe 2008). Then the drug crosses the cellular membrane and increases the cellular metabolism. Finally it aids in cell repair. Fig 2: competition of Naloxone with the opioid agonists. (Harvey and Champe 2008). Pharmacology: Naloxone is a pure competitive antagonist for the mu receptors. Mu receptors are responsible for miosis, euphoria, feeding, sedation and respiratory depression. Naloxone binds to the competitive receptors such that their antagonists or partial antagonists or mixed agonist- antagonist binding without any independent action. (Flomenbaum et al. 2006). The pharmacokinetics of naloxone differs from the other antagonists. Some studies have also found that extreme low doses of naloxone (0.25 micrograms per

Homework Wk 3 Assignment Example | Topics and Well Written Essays - 750 words

Homework Wk 3 - Assignment Example a. US Treasury Bills – Although it is the most liquid short-term security it is considered as risk-free investment. This could lead to potential disadvantage for corporations’ cash management because the yields of these securities are nominal that may not be sufficient for current cash requirements. b. Ordinary Preferred Stock – It allows a company to raise capital without diluting voting rights where the investor is eligible to receive regular dividends. This is in contrast to the nature of pure equity where investor shares risk of firm. This would require regular cash outflow by the firm. c. NCDs – They allow the companies to raise capital from investors by promising returns at specified rate of interest on deposit. NCDs also allow the investor to trade security in stock markets so that investor may exit the option before maturity. But when the corporation is not able to earn regular cash as a result of which its weighted average cost of capital exceeds interest earned then NCDs may become a burden for the corporate. d. Commercial Papers – They are issued by corporations having good credit ratings and market reputation allowing them to raise capital from investors directly without any intermediary (like banks). This reduces the cost of borrowing but requires company to repay investor at own expense. From given information if the cost of carrying per phone is $26 per year and fixed order cost is $340 then carrying cost per phone is approximately 13.08 (that is, 340/26) and total carrying cost for 740 phones is approximately $9676.92 (that is, 13.08 x 740). From the above calculations it is clear that the company should increase order size as the storage cost is cheaper than cost of carry. Also, the optimal inventory policy would require the company to produce 38 phones [since, √ [2 x 740 x (340/26)] = 38.04]. JIT inventory management system allows manufacturer to eliminate

Activity Based Costing Essay Example | Topics and Well Written Essays - 1000 words

Activity Based Costing - Essay Example More than that, it traces back the cost to the activities and processes (Heisinger, 2010). Above all, use of activity based costing (ABC) method especially in companies with diverse centers and distribution channels has proven to be suitable. Unlike other methods, the activity based costing (ABC) method ensures that there exists a direct correlation between the related overhead costs and the occurrence of an activity (Chang, 2010). Without doubt, the marketing manager decision to use the activity based costing (ABC) method, as a way of critically analyzing the customer support and distribution costs is more suitable, as compared to taking the store with the highest contribution margin ratio.... Without doubt, the marketing manager decision to use the activity based costing (ABC) method, as a way of critically analyzing the customer support and distribution costs is more suitable, as compared to taking the store with the highest contribution margin ratio. Workings Cost allocation based on revenue Total revenue is $ 500,000 1) Department Stores = $150,000/ $500,000 = 0.3 2) Specialty Shops = $100,000/ 500,000 = 0.2 3) Gift Shops = $250,000/500,000 = 0.5 (Bragg, 2002) i) Variable production cost is $150,000 Department Stores = $150,000 * 0.3= $45,000 Specialty Shops = $150,000 * 0.2 = $ 30,000 Gift Shops = $150,000 * 0.5 = $ 75,000 ii) Production Overhead $120,000 Department Stores = $120,000 * 0.3= $36,000 Specialty Shops = $120,000 * 0.2 = $ 24,000 Gift Shops = $120,000 * 0.5 = $ 60,000 iii) Selling & Distribution Costs $180,000 Department Stores = $180,000 * 0.3= $54,000 Specialty Shops = $180,000 * 0.2 = $ 36,000 Gift Shops = $180,000 * 0.5 = $ 90,000 Activity Based Costin g (ABC). Total costs/No of orders places $40,000 10 90 900 Cost drive is the number of orders placed Department Stores = $40,000 * 10/1000= $400 Specialty Shops = $40,000 * 90/1000 = $ 3,600 Gift Shops = $40,000 * 900/1000 = $ 36,000 (Finkler, Ward & Baker, 2007) Total costs/No of sales calls 80,000 5 195 800 Cost drive is the number of sales calls Department Stores = $80,000 * 5/1000= $400 Specialty Shops = $80,000 * 195/1000 = $ 15,600 Gift Shops = $80,000 * 800/1000 = $ 64,000 Total costs/No of shipments 60,000 20 480 1,000 Department Stores = $60,000 * 20/1500= $800 Specialty Shops = $60,000 * 480/1500 = $ 19,200 Gift Shops = $60,000 * 1000/1500 = $ 40,000 Allocation of other costs is based on the

Cognitive and language development Essay Example | Topics and Well Written Essays - 2500 words

Cognitive and language development - Essay Example Like different species of this environment, animals rely on camouflage, feathers and fur coats, and speed may be some of the things that they use to adapt to the environment they live in. Human beings, on the other hand work upon adapting to their environment, with the help of thinking. Through this, they not only adapt to their environment but also transform it. Hence, we can say that among all the species that live in this environment, we as human beings stand apart because of our mental faculties. Children move from simple to complex tasks, while attaining their cognitive skills. They become more and more effective thinkers with their progressing age. It’s important to note that the mental faculties of a child are not incomplete or less effective than that of adults. But we can see that the child’s focus on a limited amount of information might be adaptive (Bjorklund and Blasi, 2011). Jean Piaget was a Swiss cognitive theorist who completed his education in zoology a nd gave a biological explanation to the things he saw happening in his environment in terms of cognitive development. He viewed cognitive development as an adaptive process in which thinking develops gradually from its less oriented form to something that is driven by logic. It slowly and steadily emerges out to be a fit with the external reality. Piaget’s had a constructivist approach towards the idea of cognitive development. He said that children develop their cognitive skills by progressing via four universal stages. The names of the stages are The Sensorimotor Stage, The Preoperational Stage, The Concrete Operational Stage and The Formal Operational stage (Ginsberg and Opper, 1979). All these constructs that he gave, came under the purview of the theory he gave which he named as the Cognitive Developmental Theory. Vygotsky gave the Sociocultural Theory. In it he devised, that language is a very important determinant of cognitive development and it broadens the purview of cognition of children with the help engagement in dialogues and conversations with people around them, who provide them with new knowledge and reinforce them to master socially relevant and culturally important tasks driven by the norms and values prescribed by the environment they are residing in. According to him the important determinant of cognitive development as it occurs in the life of a child are the social experiences he/she goes through. There are many differences that we come across while trying to decipher the basic nature of both these theories. The very nature of both these theories is different. Piaget devised the theory in terms of the four stages a child progresses through but Vygotsky based his theory on the foundation of developing the basic ideas which are required for the construction of knowledge wherein the concepts of learning play a huge role in the development. According to him development cannot be separated from social contexts a child has to live in, wh ich also involves effective conversations with the significant others with the help of language. This tells us that the most evident difference between the two theories is that Piaget’s theory is hierarchical in nature but on the other hand, we don’t come to see any kind of stagewise progression in Vygotsky’s theory. This tells us that each of the Piaget’s preceding stages must be accomplished before the child moves on to the

Annotated bibliography Example | Topics and Well Written Essays - 250 words - 6

Annotated Bibliography Example The method that has been used by the author is order to conduct the research is the case study with an authentic usage of parallelism. There are many cases and facts that have been brought to life by the author. The reason behind using this source for the paper is because it reveals many important reasons behind the development and transitions between older and modern communities. The second source taken for the purpose of research work is one that has been cited by various researchers. It is mainly because the source makes use of a wide array of cases, chronology, illustrations that indicate the readers about the history of Europe during 1648 till 1815. The objective of the source is to discuss the main conflicts that were noted or observed during the selected period. The religious factors, societal aspects and economic decline are the highlights of the book. The authors of the book have rather become the reason for high credibility of the book because they are well informed and professional able in the field of

Critical analysis Essay Example | Topics and Well Written Essays - 500 words - 1

Critical analysis - Essay Example He is put in an asylum. The place- Villete, an asylum in the city of Ljubljana. And the author- an expert storyteller, Paulo Coelho. Though, the plot of the story may sound gloomy but the story keeps the reader engaged as it unwinds. Because, you can relate to atleast one of the characters, you are eager to find out what happens next. You want to know the path taken up by the characters. Perhaps, you could follow the same. And the path that you should follow in life is revealed by Paulo Coelho in the most amazing way. You will find it difficult, if not difficult, impossible to disagree with him. The battle of every character is painted by Paulo Coelho with great detail. On one fine day (11 November 1997), Veronika simply decides to die. She swallows sleeping pills and peacefully waits for her death. She could have used some other method of committing suicide but the book explains why she uses sleeping pills- â€Å"Obviously she could have thrown herself off one of the few tall buildings in Ljubljana, but what about the further suffering caused to her parents by a fall from such a height?† Veronika fails to realize that her death will, anyway, bring misery to her parents. Veronika is saved and admitted to an asylum. In the asylum, she is told by Dr.Igor that her suicide attempt has succeeded but she will live for another five days before she dies. Veronika had planned to die quickly. But waiting for your death is different. And so, begins the five day ordeal for Veronika. Many of us commit suicide and die a cowardly death. This happens in a matter of a few minutes. How quickly the scenario changes when you have to wait for your death! You know that every minute is taking you towards death. And so you want to make the most of it. That is what happens to Veronika. At the asylum, Veronika meets other ‘mad’ people.

Hometown Standpoint Essay Example | Topics and Well Written Essays - 250 words

Hometown Standpoint - Essay Example I come from Saudi Arabia. The family is considered the basic unit of society and members are inherently unified as well as supportive of each other from birth until adulthood. The relevant characters in my life are members of my nuclear family: my mother, brother and sister. My father died in 2001. When I got married, it was my mother who stood by me. In addition to my nuclear family, I consider my spouse and my two children relevant characters in my life. I played football as member of the national team for 20 years before my father died. When I came to America in 2011 with my wife, I started pursuing higher education. Recently, my mother was diagnosed with cancer and sought treatment a year ago. As such, from one’s standpoint, I strongly believe that as the male member of the family, considered the source of strength and support, I should strive to achieve personal and professional goals that aim improving the lives of the members of my family. All my plans and actions are undertaken to generate financial resources needed to support my children and spouse, as well as seek treatment for my mother’s illness. Since my father’s death, his absence left a void in terms of his physical and emotional support that he showered us when he was alive. As such, I try to make up for my father’s absence by frequent monitoring of my mother’s health condition. I firmly believe that the importance relegated to the fa mily as a close-knit unit of society in our culture contributed to my immense commitment to ensure that all members communicate with each other despite differences in geographic